Structures, Functions and Therapeutic Potential of Cyclotides

Background and objectivesPlants usually produce a large number of secondary metabolite molecules, including antimicrobial peptides that typically interact with membranes pathogens kill these. Cysteine is more abundant in plant than other sources. These phytopeptides can be classified into 5–8 distinct groups, based on the length, structure type, model disulphide bridges, others. Among different groups phytopeptides, cyclotides are end-to-end cyclic bridge knot fashion. Cyclotide primarily known for its anti-nematode, anti-mollusk, anti-trematode action. This review aims to provide detailed insights cyclotides, from their origin, structural functional characterization, therapeutic potential, biotechnological application, future prospective.